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Nicotine, the principal component of TS and e-cig, can negatively affect tight junctional protein expression, compromising BBB integrity (Hawkins et al., 2004)

The HPV vaccines, like other immunizations that guard against viral infection, stimulate the body to produce antibodies that attack if they encounter the HPV infection by binding to the virus and preventing it from infecting cells

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Therefore, adding messages that are convincing for behavioral changings together with the helpline may be effective as well